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Schizandrin A

CAS No. 61281-38-7

Schizandrin A ( Deoxyschisandrin | Deoxyschizandrin | Schizandrin A )

产品货号. M18895 CAS No. 61281-38-7

五味子甲素是从东方药物五味子中提取的主要有效成分,抑制 CYP3A 活性,IC50 为 6.60 μM,Ki 为 5.83 μM。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
10MG ¥300 有现货
25MG ¥454 有现货
50MG ¥640 有现货
100MG ¥932 有现货
500MG ¥2349 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Schizandrin A
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    五味子甲素是从东方药物五味子中提取的主要有效成分,抑制 CYP3A 活性,IC50 为 6.60 μM,Ki 为 5.83 μM。
  • 产品描述
    Schizandrin A, also known as Deoxyschizandrin, is a bio-active isolate of Schisandra chinensis. Schizandrin A protects against cerebral ischemia-reperfusion injury by suppressing inflammation and oxidative stress and regulating the AMPK/Nrf2 pathway regulation. Schisandrin A prevents oxidative stress-induced DNA damage and apoptosis by attenuating ROS generation in C2C12 cells.(In Vitro):Schisandrin A (Sch A) strongly inhibits microsomal midazolam 1-hydroxylation catalyzed by CYP3A, with an IC50 of 6.60 μM. The recovery of enzyme activity in the absence or presence of Schisandrin A is shown in dilution assay plots. The Ki value for Schisandrin A is obtained from the Dixon plots and is 5.83 μM. The inactivation of rat liver microsomal midazolam 1-hydroxylation activity by Schisandrin A in the presence of NADPH is found to be time- and concentration-dependent. The Kinact and Ki are estimated to be 0.134/min and 4.51 μM, respectively for Schisandrin A. (In Vivo):Schisandrin A (SchA) significantly inhibits CYP3A activity in rat hepatic microsomes and Vmax value of each group in a concentration-dependent manner. The double-reciprocal plots and the secondary plot show that Schisandrin A inhibits CYP3A activity, with an apparent Ki value of 30.67 mg/kg. In each Schisandrin A-treated group, Schisandrin A also significantly decreases 1-hydroxymidazolam plasma concentrations compared with the negative group (to levels similar to the positive group).
  • 体外实验
    Schisandrin A (Sch A) strongly inhibits microsomal midazolam 1-hydroxylation catalyzed by CYP3A, with an IC50 of 6.60 μM. The recovery of enzyme activity in the absence or presence of Schisandrin A is shown in dilution assay plots. The Ki value for Schisandrin A is obtained from the Dixon plots and is 5.83 μM. The inactivation of rat liver microsomal midazolam 1-hydroxylation activity by Schisandrin A in the presence of NADPH is found to be time- and concentration-dependent. The Kinact and Ki are estimated to be 0.134/min and 4.51 μM, respectively for Schisandrin A.
  • 体内实验
    Schisandrin A (SchA) significantly inhibits CYP3A activity in rat hepatic microsomes and Vmax value of each group in a concentration-dependent manner. The double-reciprocal plots and the secondary plot show that Schisandrin A inhibits CYP3A activity, with an apparent Ki value of 30.67 mg/kg. In each Schisandrin A-treated group, Schisandrin A also significantly decreases 1-hydroxymidazolam plasma concentrations compared with the negative group (to levels similar to the positive group).
  • 同义词
    Deoxyschisandrin | Deoxyschizandrin | Schizandrin A
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    Others
  • 研究领域
    Others-Field
  • 适应症
    ——

化学信息

  • CAS Number
    61281-38-7
  • 分子量
    416.51
  • 分子式
    C24H32O6
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO : 50 mg/mL 120.05 mM; H2O : < 0.1 mg/mL
  • SMILES
    C[C@@H]1Cc2cc(c(c(c2c2c(c(c(cc2C[C@@H]1C)OC)OC)OC)OC)OC)OC
  • 化学全称
    (6R,7S)-1,2,3,10,11,12-Hexamethoxy-6,7-dimethyl-5,6,7,8-tetrahydrodibenzo[a,c][8]annulene

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Wang CP, et al. J Physiol Biochem. 2014 Sep;70(3):735-47.
产品手册
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