
Schizandrin A
CAS No. 61281-38-7
Schizandrin A ( Deoxyschisandrin | Deoxyschizandrin | Schizandrin A )
产品货号. M18895 CAS No. 61281-38-7
五味子甲素是从东方药物五味子中提取的主要有效成分,抑制 CYP3A 活性,IC50 为 6.60 μM,Ki 为 5.83 μM。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
10MG | ¥300 | 有现货 |
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25MG | ¥454 | 有现货 |
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50MG | ¥640 | 有现货 |
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100MG | ¥932 | 有现货 |
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500MG | ¥2349 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Schizandrin A
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述五味子甲素是从东方药物五味子中提取的主要有效成分,抑制 CYP3A 活性,IC50 为 6.60 μM,Ki 为 5.83 μM。
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产品描述Schizandrin A, also known as Deoxyschizandrin, is a bio-active isolate of Schisandra chinensis. Schizandrin A protects against cerebral ischemia-reperfusion injury by suppressing inflammation and oxidative stress and regulating the AMPK/Nrf2 pathway regulation. Schisandrin A prevents oxidative stress-induced DNA damage and apoptosis by attenuating ROS generation in C2C12 cells.(In Vitro):Schisandrin A (Sch A) strongly inhibits microsomal midazolam 1-hydroxylation catalyzed by CYP3A, with an IC50 of 6.60 μM. The recovery of enzyme activity in the absence or presence of Schisandrin A is shown in dilution assay plots. The Ki value for Schisandrin A is obtained from the Dixon plots and is 5.83 μM. The inactivation of rat liver microsomal midazolam 1-hydroxylation activity by Schisandrin A in the presence of NADPH is found to be time- and concentration-dependent. The Kinact and Ki are estimated to be 0.134/min and 4.51 μM, respectively for Schisandrin A. (In Vivo):Schisandrin A (SchA) significantly inhibits CYP3A activity in rat hepatic microsomes and Vmax value of each group in a concentration-dependent manner. The double-reciprocal plots and the secondary plot show that Schisandrin A inhibits CYP3A activity, with an apparent Ki value of 30.67 mg/kg. In each Schisandrin A-treated group, Schisandrin A also significantly decreases 1-hydroxymidazolam plasma concentrations compared with the negative group (to levels similar to the positive group).
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体外实验Schisandrin A (Sch A) strongly inhibits microsomal midazolam 1-hydroxylation catalyzed by CYP3A, with an IC50 of 6.60 μM. The recovery of enzyme activity in the absence or presence of Schisandrin A is shown in dilution assay plots. The Ki value for Schisandrin A is obtained from the Dixon plots and is 5.83 μM. The inactivation of rat liver microsomal midazolam 1-hydroxylation activity by Schisandrin A in the presence of NADPH is found to be time- and concentration-dependent. The Kinact and Ki are estimated to be 0.134/min and 4.51 μM, respectively for Schisandrin A.
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体内实验Schisandrin A (SchA) significantly inhibits CYP3A activity in rat hepatic microsomes and Vmax value of each group in a concentration-dependent manner. The double-reciprocal plots and the secondary plot show that Schisandrin A inhibits CYP3A activity, with an apparent Ki value of 30.67 mg/kg. In each Schisandrin A-treated group, Schisandrin A also significantly decreases 1-hydroxymidazolam plasma concentrations compared with the negative group (to levels similar to the positive group).
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同义词Deoxyschisandrin | Deoxyschizandrin | Schizandrin A
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通路Others
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靶点Other Targets
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受体Others
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研究领域Others-Field
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适应症——
化学信息
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CAS Number61281-38-7
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分子量416.51
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分子式C24H32O6
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纯度>98% (HPLC)
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溶解度DMSO : 50 mg/mL 120.05 mM; H2O : < 0.1 mg/mL
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SMILESC[C@@H]1Cc2cc(c(c(c2c2c(c(c(cc2C[C@@H]1C)OC)OC)OC)OC)OC)OC
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化学全称(6R,7S)-1,2,3,10,11,12-Hexamethoxy-6,7-dimethyl-5,6,7,8-tetrahydrodibenzo[a,c][8]annulene
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Wang CP, et al. J Physiol Biochem. 2014 Sep;70(3):735-47.
产品手册




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